Zoloft (Sertraline)
Zoloft is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It works by increasing serotonin levels in the brain, which helps improve mood, emotion, and mental balance.
Uses
Zoloft is used to treat:
- Depression
- Anxiety disorders (Generalized Anxiety Disorder, Panic Disorder)
- Obsessive-Compulsive Disorder (OCD)
- Post-Traumatic Stress Disorder (PTSD)
- Social Anxiety Disorder
- Premenstrual Dysphoric Disorder (PMDD)
Dosage
Dosage varies based on the condition being treated and patient response. A doctor will determine the appropriate dose.
Typical Adult Dosage:
- Depression & OCD: Start with 50 mg once daily, can be increased up to 200 mg per day.
- Panic Disorder, PTSD, Social Anxiety Disorder: Start with 25 mg once daily, increase to 50 mg after a week, with a maximum of 200 mg per day.
- PMDD: 50 mg per day during the menstrual cycle or throughout the month.
Administration:
- Take with or without food at the same time each day.
- Do not crush or chew tablets.
- It may take several weeks to feel full benefits.
Side Effects
Common side effects include:
- Nausea
- Diarrhea
- Dry mouth
- Drowsiness or Insomnia
- Dizziness
- Increased sweating
- Decreased libido or sexual dysfunction
Serious side effects (seek medical attention):
- Suicidal thoughts (especially in young adults)
- Serotonin syndrome (agitation, hallucinations, fever, sweating, fast heartbeat, muscle stiffness)
- Severe allergic reactions
Precautions
- Do not use if allergic to Sertraline.
- Avoid alcohol while taking Zoloft.
- Use with caution in patients with liver disease, epilepsy, or bleeding disorders.
- Pregnancy & Breastfeeding: Consult a doctor before use.
- Monitor for mood changes, especially in young adults starting the medication.
Drug Interactions
- Do not take with MAOIs (e.g., Selegiline, Phenelzine) – can cause dangerous interactions.
- Can interact with blood thinners (e.g., Warfarin), NSAIDs, and other antidepressants.
- Avoid St. John's Wort and other herbal supplements that affect serotonin.
Who Can Take Zoloft?
- Adults and adolescents (depending on the condition).
- Those diagnosed with depression, anxiety, OCD, PTSD, or PMDD.
Who Should Avoid Zoloft?
- Those with a history of serotonin syndrome.
- Patients taking MAOIs or Pimozide.
- Individuals with severe liver disease or uncontrolled epilepsy.
Consult a Healthcare Provider
Always talk to your doctor before starting or stopping Zoloft. Never abruptly stop taking it, as withdrawal symptoms can occur.
Zoloft is a widely used antidepressant that helps manage mood disorders by regulating serotonin. While it can be life-changing for many, it's essential to take it exactly as prescribed, be mindful of possible side effects, and consult your doctor if you experience any unusual symptoms.